This paper is a result of a cross ANSP review of the different regulatory and scientific developments and provides consolidated information on what stress, fatigue, psychoactive substances and rosters are. It provides guidance to ATCOs and ANSP managers on the different approaches that can utilised in order to embrace and move forward to achieve compliance with the new regulatory provisions. The paper starts with an illustrative case study based loosely on a real life incident that happened to our fictional colleague, Alice. It shows that we are all only human and that these new regulations should be seen by all of us as an opportunity to improve.