Flying is a complex task that requires the full cognitive, judgemental and psychomotor capabilities of a pilot. If these abilities are impaired to any extent, safety can be compromised. Many conditions and substances can cause impairment. For example, all humans occasionally have mild illnesses such as colds that can potentially impair their performance. Some people have chronic conditions such as high blood pressure or elevated cholesterol that are not disabling but require the use of medication to control symptoms. Drugs, both prescription and over-the-counter, can relieve symptoms and, perhaps, even cure the illness. Many people routinely drink alcoholic and/or caffeinated beverages. Each of these uses of drugs, as well as other lifestyle activities, can affect flying, particularly on long-range, monotonous flights, impair the pilot’s abilities and compromise safety.