The most critical product of aircraft fuselage fires is the smoke gases which are produced by combustion in the cabin environment.
The increased use of flame-retardant materials for cabin furnishings has reduced smoke gas production; however, once a fire takes hold, the materials used for cabin trim and fittings still generate substantial visible smoke. Some of the gas constituents of this smoke are especially, and very rapidly, disabling.
Inhalation of toxic gases in smoke is the main direct cause of fatalities in most aircraft fires. To survive, significant inhalation of these gases must be avoided and some oxygen intake maintained until evacuation is possible. Minimising exposure to abnormal gases, both the directly toxic and otherwise, will also limit the irritant effects on the eyes.